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Engineering Complex Systems for Predictive Toxicology in the Animal-free Zone: Modeling Cellular Dynamics in silico
Citation:
Knudsen, T. Engineering Complex Systems for Predictive Toxicology in the Animal-free Zone: Modeling Cellular Dynamics in silico. Society of Toxicology, Risk Assessment Specialty Section, NA, NC, April 12, 2023. https://doi.org/10.23645/epacomptox.22670287
Impact/Purpose:
This is an invited webinar presentation to the Society of Toxicology Risk Assessment Specialty Section (RASS) monthly webinar series April 2023, which will be part 2 of a tandem presentation.
Description:
New Approach Methods (NAMs) refers to 21st-C testing strategies that rely on in vitro data and in silico models to predict human toxicity with less reliance on animal testing. Complex NAMs that accurately predict the potential for human developmental toxicity are needed to succeed or supersede conventional testing in pregnant animals. Most in vitro assays lack the positional information, physical constraints, and regional organization of a multicellular system undergoing morphogenesis and development. Embryo-inspired computational (in silico) models with emergent, self-organizing capacity can simulate critical phase transitions during developmental processes and toxicities. Will a virtual tissue model of physical trajectory hold up to the mechanistic veracity needed to reliably predict toxicological outcome(s) in a complex system? DISCLAIMER: The views expressed are those of the presenters and do not reflect Agency policy.
URLs/Downloads:
DOI: Engineering Complex Systems for Predictive Toxicology in the Animal-free Zone: Modeling Cellular Dynamics in silico
RASS_KNUDSEN.PDF (PDF, NA pp, 5526.708 KB, about PDF)